Combined Oral Contraceptives and Lamotrigine: Drug Interaction Guide

Quick answer: This combination requires caution. Combined Oral Contraceptives and Lamotrigine can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Combined Oral Contraceptives interacts with Lamotrigine

Ethinylestradiol induces UGT-mediated glucuronidation of lamotrigine, lowering lamotrigine concentrations. Lamotrigine levels can rise during hormone-free intervals.

What you should do

Monitor seizure or mood control and adjust lamotrigine dose when starting or stopping combined hormonal contraception. Consider continuous regimens or non-estrogen contraception when appropriate.

Key facts

Severity

Moderate — caution required

Mechanism

Ethinylestradiol induces UGT-mediated glucuronidation of lamotrigine, lowering lamotrigine concentrations. Lamotrigine l...

Action

Monitor seizure or mood control and adjust lamotrigine dose when starting or stopping combined hormonal contraception. C...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Combined Oral Contraceptives and Lamotrigine together?

With caution. Monitor seizure or mood control and adjust lamotrigine dose when starting or stopping combined hormonal contraception. Consider continuous regimens or non-estrogen contraception when appropriate.

What is the severity of this interaction?

The interaction between Combined Oral Contraceptives and Lamotrigine is classified as Moderate — caution required. Ethinylestradiol induces UGT-mediated glucuronidation of lamotrigine, lowering lamotrigine concentrations. Lamotrigine levels can rise during hormone-free intervals.

What should I do if I'm prescribed both?

Monitor seizure or mood control and adjust lamotrigine dose when starting or stopping combined hormonal contraception. Consider continuous regimens or non-estrogen contraception when appropriate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.