Mycophenolate and Oral Contraceptives: Drug Interaction Guide

Quick answer: This combination requires caution. Mycophenolate and Oral Contraceptives can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Mycophenolate interacts with Oral Contraceptives

Mycophenolate may reduce ethinylestradiol exposure through enterohepatic disruption, potentially reducing contraceptive efficacy, while pregnancy is teratogenic.

What you should do

Use two reliable contraceptive methods (e.g., COC plus barrier) before, during, and 6 weeks after mycophenolate therapy.

Key facts

Severity

Moderate — caution required

Mechanism

Mycophenolate may reduce ethinylestradiol exposure through enterohepatic disruption, potentially reducing contraceptive ...

Action

Use two reliable contraceptive methods (e.g., COC plus barrier) before, during, and 6 weeks after mycophenolate therapy.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Mycophenolate and Oral Contraceptives together?

With caution. Use two reliable contraceptive methods (e.g., COC plus barrier) before, during, and 6 weeks after mycophenolate therapy.

What is the severity of this interaction?

The interaction between Mycophenolate and Oral Contraceptives is classified as Moderate — caution required. Mycophenolate may reduce ethinylestradiol exposure through enterohepatic disruption, potentially reducing contraceptive efficacy, while pregnancy is teratogenic.

What should I do if I'm prescribed both?

Use two reliable contraceptive methods (e.g., COC plus barrier) before, during, and 6 weeks after mycophenolate therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.