Cyclosporine and Grapefruit Juice: Drug Interaction Guide

Quick answer: This combination requires caution. Cyclosporine and Grapefruit Juice can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Cyclosporine interacts with Grapefruit Juice

Grapefruit juice inhibits intestinal CYP3A4 and P-glycoprotein, increasing cyclosporine bioavailability. This can increase nephrotoxicity, hypertension, and other concentration-related adverse effects.

What you should do

Advise patients to avoid grapefruit and grapefruit juice. Monitor cyclosporine trough concentrations and renal function if exposure occurs.

Key facts

Severity

Moderate — caution required

Mechanism

Grapefruit juice inhibits intestinal CYP3A4 and P-glycoprotein, increasing cyclosporine bioavailability. This can increa...

Action

Advise patients to avoid grapefruit and grapefruit juice. Monitor cyclosporine trough concentrations and renal function ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Cyclosporine and Grapefruit Juice together?

With caution. Advise patients to avoid grapefruit and grapefruit juice. Monitor cyclosporine trough concentrations and renal function if exposure occurs.

What is the severity of this interaction?

The interaction between Cyclosporine and Grapefruit Juice is classified as Moderate — caution required. Grapefruit juice inhibits intestinal CYP3A4 and P-glycoprotein, increasing cyclosporine bioavailability. This can increase nephrotoxicity, hypertension, and other concentration-related adverse effects.

What should I do if I'm prescribed both?

Advise patients to avoid grapefruit and grapefruit juice. Monitor cyclosporine trough concentrations and renal function if exposure occurs. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.