Cyclosporine and Simvastatin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Cyclosporine and Simvastatin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Cyclosporine interacts with Simvastatin

Cyclosporine inhibits CYP3A4 and OATP1B1 transporters, increasing simvastatin exposure several-fold and markedly raising the risk of myopathy and rhabdomyolysis.

What you should do

Avoid simvastatin in patients on cyclosporine; switch to pravastatin or fluvastatin with cautious dose titration.

Key facts

Severity

Major — avoid combination

Mechanism

Cyclosporine inhibits CYP3A4 and OATP1B1 transporters, increasing simvastatin exposure several-fold and markedly raising...

Action

Avoid simvastatin in patients on cyclosporine; switch to pravastatin or fluvastatin with cautious dose titration.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Cyclosporine and Simvastatin together?

No — this combination should generally be avoided. Avoid simvastatin in patients on cyclosporine; switch to pravastatin or fluvastatin with cautious dose titration.

What is the severity of this interaction?

The interaction between Cyclosporine and Simvastatin is classified as Major — avoid combination. Cyclosporine inhibits CYP3A4 and OATP1B1 transporters, increasing simvastatin exposure several-fold and markedly raising the risk of myopathy and rhabdomyolysis.

What should I do if I'm prescribed both?

Avoid simvastatin in patients on cyclosporine; switch to pravastatin or fluvastatin with cautious dose titration. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.