Ritonavir and Simvastatin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ritonavir and Simvastatin unless specifically directed by your doctor.
How Ritonavir interacts with Simvastatin
Ritonavir is a potent CYP3A4 inhibitor that raises simvastatin exposure dramatically, with high risk of rhabdomyolysis.
What you should do
Co-administration of simvastatin (and lovastatin) with ritonavir-boosted regimens is contraindicated. Switch to pravastatin, pitavastatin, or low-dose rosuvastatin.
Key facts
Severity
Major — avoid combination
Mechanism
Ritonavir is a potent CYP3A4 inhibitor that raises simvastatin exposure dramatically, with high risk of rhabdomyolysis.
Action
Co-administration of simvastatin (and lovastatin) with ritonavir-boosted regimens is contraindicated. Switch to pravasta...
Frequently asked questions
Can I take Ritonavir and Simvastatin together?
No — this combination should generally be avoided. Co-administration of simvastatin (and lovastatin) with ritonavir-boosted regimens is contraindicated. Switch to pravastatin, pitavastatin, or low-dose rosuvastatin.
What is the severity of this interaction?
The interaction between Ritonavir and Simvastatin is classified as Major — avoid combination. Ritonavir is a potent CYP3A4 inhibitor that raises simvastatin exposure dramatically, with high risk of rhabdomyolysis.
What should I do if I'm prescribed both?
Co-administration of simvastatin (and lovastatin) with ritonavir-boosted regimens is contraindicated. Switch to pravastatin, pitavastatin, or low-dose rosuvastatin. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.