Cyclosporine and Verapamil: Drug Interaction Guide

Quick answer: This combination requires caution. Cyclosporine and Verapamil can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Cyclosporine interacts with Verapamil

Verapamil inhibits CYP3A4 and P-glycoprotein, reducing cyclosporine clearance. Cyclosporine exposure may increase, raising nephrotoxicity and hypertension risk.

What you should do

Monitor cyclosporine trough concentrations, renal function, and blood pressure; adjust cyclosporine dose as needed.

Key facts

Severity

Moderate — caution required

Mechanism

Verapamil inhibits CYP3A4 and P-glycoprotein, reducing cyclosporine clearance. Cyclosporine exposure may increase, raisi...

Action

Monitor cyclosporine trough concentrations, renal function, and blood pressure; adjust cyclosporine dose as needed.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Cyclosporine and Verapamil together?

With caution. Monitor cyclosporine trough concentrations, renal function, and blood pressure; adjust cyclosporine dose as needed.

What is the severity of this interaction?

The interaction between Cyclosporine and Verapamil is classified as Moderate — caution required. Verapamil inhibits CYP3A4 and P-glycoprotein, reducing cyclosporine clearance. Cyclosporine exposure may increase, raising nephrotoxicity and hypertension risk.

What should I do if I'm prescribed both?

Monitor cyclosporine trough concentrations, renal function, and blood pressure; adjust cyclosporine dose as needed. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.