Digoxin and Itraconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Digoxin and Itraconazole unless specifically directed by your doctor.
How Digoxin interacts with Itraconazole
Itraconazole inhibits P-glycoprotein-mediated renal tubular secretion of digoxin, increasing digoxin levels by 50-100% and risking arrhythmia and AV block.
What you should do
Reduce digoxin dose by 50% and monitor serum digoxin levels and ECG within 5-7 days of starting itraconazole.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole inhibits P-glycoprotein-mediated renal tubular secretion of digoxin, increasing digoxin levels by 50-100% a...
Action
Reduce digoxin dose by 50% and monitor serum digoxin levels and ECG within 5-7 days of starting itraconazole.
Frequently asked questions
Can I take Digoxin and Itraconazole together?
No — this combination should generally be avoided. Reduce digoxin dose by 50% and monitor serum digoxin levels and ECG within 5-7 days of starting itraconazole.
What is the severity of this interaction?
The interaction between Digoxin and Itraconazole is classified as Major — avoid combination. Itraconazole inhibits P-glycoprotein-mediated renal tubular secretion of digoxin, increasing digoxin levels by 50-100% and risking arrhythmia and AV block.
What should I do if I'm prescribed both?
Reduce digoxin dose by 50% and monitor serum digoxin levels and ECG within 5-7 days of starting itraconazole. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.