Itraconazole and Simvastatin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Itraconazole and Simvastatin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Itraconazole interacts with Simvastatin

Itraconazole is a strong CYP3A4 inhibitor and greatly increases simvastatin exposure. This increases the risk of severe myopathy and rhabdomyolysis.

What you should do

Contraindicated or avoid; stop simvastatin during itraconazole treatment or use a statin not dependent on CYP3A4.

Key facts

Severity

Major — avoid combination

Mechanism

Itraconazole is a strong CYP3A4 inhibitor and greatly increases simvastatin exposure. This increases the risk of severe ...

Action

Contraindicated or avoid; stop simvastatin during itraconazole treatment or use a statin not dependent on CYP3A4.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Itraconazole and Simvastatin together?

No — this combination should generally be avoided. Contraindicated or avoid; stop simvastatin during itraconazole treatment or use a statin not dependent on CYP3A4.

What is the severity of this interaction?

The interaction between Itraconazole and Simvastatin is classified as Major — avoid combination. Itraconazole is a strong CYP3A4 inhibitor and greatly increases simvastatin exposure. This increases the risk of severe myopathy and rhabdomyolysis.

What should I do if I'm prescribed both?

Contraindicated or avoid; stop simvastatin during itraconazole treatment or use a statin not dependent on CYP3A4. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.