Donepezil and Succinylcholine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Donepezil and Succinylcholine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Donepezil interacts with Succinylcholine

Donepezil inhibits acetylcholinesterase and pseudocholinesterase, prolonging the duration of succinylcholine-induced neuromuscular blockade and apnoea during anaesthesia.

What you should do

Inform anaesthesia preoperatively and consider holding donepezil for 2-3 weeks before elective surgery or using a non-depolarising neuromuscular blocker instead.

Key facts

Severity

Major — avoid combination

Mechanism

Donepezil inhibits acetylcholinesterase and pseudocholinesterase, prolonging the duration of succinylcholine-induced neu...

Action

Inform anaesthesia preoperatively and consider holding donepezil for 2-3 weeks before elective surgery or using a non-de...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Donepezil and Succinylcholine together?

No — this combination should generally be avoided. Inform anaesthesia preoperatively and consider holding donepezil for 2-3 weeks before elective surgery or using a non-depolarising neuromuscular blocker instead.

What is the severity of this interaction?

The interaction between Donepezil and Succinylcholine is classified as Major — avoid combination. Donepezil inhibits acetylcholinesterase and pseudocholinesterase, prolonging the duration of succinylcholine-induced neuromuscular blockade and apnoea during anaesthesia.

What should I do if I'm prescribed both?

Inform anaesthesia preoperatively and consider holding donepezil for 2-3 weeks before elective surgery or using a non-depolarising neuromuscular blocker instead. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.