Neostigmine and Succinylcholine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Neostigmine and Succinylcholine unless specifically directed by your doctor.
How Neostigmine interacts with Succinylcholine
Neostigmine inhibits plasma cholinesterase, the enzyme that hydrolyses succinylcholine, prolonging neuromuscular blockade and apnoea.
What you should do
Avoid neostigmine within several hours of succinylcholine administration; ensure adequate spontaneous recovery before reversing with anticholinesterase agents.
Key facts
Severity
Major — avoid combination
Mechanism
Neostigmine inhibits plasma cholinesterase, the enzyme that hydrolyses succinylcholine, prolonging neuromuscular blockad...
Action
Avoid neostigmine within several hours of succinylcholine administration; ensure adequate spontaneous recovery before re...
Frequently asked questions
Can I take Neostigmine and Succinylcholine together?
No — this combination should generally be avoided. Avoid neostigmine within several hours of succinylcholine administration; ensure adequate spontaneous recovery before reversing with anticholinesterase agents.
What is the severity of this interaction?
The interaction between Neostigmine and Succinylcholine is classified as Major — avoid combination. Neostigmine inhibits plasma cholinesterase, the enzyme that hydrolyses succinylcholine, prolonging neuromuscular blockade and apnoea.
What should I do if I'm prescribed both?
Avoid neostigmine within several hours of succinylcholine administration; ensure adequate spontaneous recovery before reversing with anticholinesterase agents. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.