Doxycycline and Rifampicin: Drug Interaction Guide
Quick answer: This combination requires caution. Doxycycline and Rifampicin can be used together with adjustments and monitoring.
How Doxycycline interacts with Rifampicin
Rifampicin induces CYP3A4 and other oxidative enzymes that metabolise doxycycline, halving its serum half-life and trough concentrations.
What you should do
Either increase doxycycline to 100 mg twice daily or select an alternative antibiotic when concurrent rifampicin therapy is unavoidable.
Key facts
Severity
Moderate — caution required
Mechanism
Rifampicin induces CYP3A4 and other oxidative enzymes that metabolise doxycycline, halving its serum half-life and troug...
Action
Either increase doxycycline to 100 mg twice daily or select an alternative antibiotic when concurrent rifampicin therapy...
Frequently asked questions
Can I take Doxycycline and Rifampicin together?
With caution. Either increase doxycycline to 100 mg twice daily or select an alternative antibiotic when concurrent rifampicin therapy is unavoidable.
What is the severity of this interaction?
The interaction between Doxycycline and Rifampicin is classified as Moderate — caution required. Rifampicin induces CYP3A4 and other oxidative enzymes that metabolise doxycycline, halving its serum half-life and trough concentrations.
What should I do if I'm prescribed both?
Either increase doxycycline to 100 mg twice daily or select an alternative antibiotic when concurrent rifampicin therapy is unavoidable. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.