Dronedarone and Rivaroxaban: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Dronedarone and Rivaroxaban unless specifically directed by your doctor.
How Dronedarone interacts with Rivaroxaban
Dronedarone inhibits both CYP3A4 and P-glycoprotein, markedly increasing rivaroxaban exposure and bleeding risk in patients already at high thrombotic risk.
What you should do
Avoid the combination per product labelling. If anticoagulation is needed alongside dronedarone, consider an alternative such as apixaban or a vitamin K antagonist with INR monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Dronedarone inhibits both CYP3A4 and P-glycoprotein, markedly increasing rivaroxaban exposure and bleeding risk in patie...
Action
Avoid the combination per product labelling. If anticoagulation is needed alongside dronedarone, consider an alternative...
Frequently asked questions
Can I take Dronedarone and Rivaroxaban together?
No — this combination should generally be avoided. Avoid the combination per product labelling. If anticoagulation is needed alongside dronedarone, consider an alternative such as apixaban or a vitamin K antagonist with INR monitoring.
What is the severity of this interaction?
The interaction between Dronedarone and Rivaroxaban is classified as Major — avoid combination. Dronedarone inhibits both CYP3A4 and P-glycoprotein, markedly increasing rivaroxaban exposure and bleeding risk in patients already at high thrombotic risk.
What should I do if I'm prescribed both?
Avoid the combination per product labelling. If anticoagulation is needed alongside dronedarone, consider an alternative such as apixaban or a vitamin K antagonist with INR monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.