Dronedarone and Simvastatin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Dronedarone and Simvastatin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Dronedarone interacts with Simvastatin

Dronedarone inhibits CYP3A4 and OATP1B1, increasing simvastatin exposure and the risk of myopathy and rhabdomyolysis.

What you should do

Limit simvastatin to 10 mg daily when combined with dronedarone, or substitute pravastatin or rosuvastatin.

Key facts

Severity

Major — avoid combination

Mechanism

Dronedarone inhibits CYP3A4 and OATP1B1, increasing simvastatin exposure and the risk of myopathy and rhabdomyolysis.

Action

Limit simvastatin to 10 mg daily when combined with dronedarone, or substitute pravastatin or rosuvastatin.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Dronedarone and Simvastatin together?

No — this combination should generally be avoided. Limit simvastatin to 10 mg daily when combined with dronedarone, or substitute pravastatin or rosuvastatin.

What is the severity of this interaction?

The interaction between Dronedarone and Simvastatin is classified as Major — avoid combination. Dronedarone inhibits CYP3A4 and OATP1B1, increasing simvastatin exposure and the risk of myopathy and rhabdomyolysis.

What should I do if I'm prescribed both?

Limit simvastatin to 10 mg daily when combined with dronedarone, or substitute pravastatin or rosuvastatin. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.