Edoxaban and Verapamil: Drug Interaction Guide

Quick answer: This combination requires caution. Edoxaban and Verapamil can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Edoxaban interacts with Verapamil

Verapamil inhibits intestinal P-glycoprotein, increasing edoxaban exposure by approximately 50% and elevating bleeding risk, especially in patients with low body weight or impaired renal function.

What you should do

Reduce edoxaban from 60 mg to 30 mg daily when used with verapamil in atrial fibrillation. Reassess if verapamil is discontinued.

Key facts

Severity

Moderate — caution required

Mechanism

Verapamil inhibits intestinal P-glycoprotein, increasing edoxaban exposure by approximately 50% and elevating bleeding r...

Action

Reduce edoxaban from 60 mg to 30 mg daily when used with verapamil in atrial fibrillation. Reassess if verapamil is disc...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Edoxaban and Verapamil together?

With caution. Reduce edoxaban from 60 mg to 30 mg daily when used with verapamil in atrial fibrillation. Reassess if verapamil is discontinued.

What is the severity of this interaction?

The interaction between Edoxaban and Verapamil is classified as Moderate — caution required. Verapamil inhibits intestinal P-glycoprotein, increasing edoxaban exposure by approximately 50% and elevating bleeding risk, especially in patients with low body weight or impaired renal function.

What should I do if I'm prescribed both?

Reduce edoxaban from 60 mg to 30 mg daily when used with verapamil in atrial fibrillation. Reassess if verapamil is discontinued. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.