Enalapril and Lithium: Drug Interaction Guide

Quick answer: This combination requires caution. Enalapril and Lithium can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Enalapril interacts with Lithium

ACE inhibitors reduce renal blood flow and aldosterone-mediated sodium excretion, increasing proximal tubular reabsorption of lithium and raising plasma levels.

What you should do

Check lithium concentration within one week of starting an ACE inhibitor and adjust dose. Maintain adequate hydration and avoid concurrent NSAIDs.

Key facts

Severity

Moderate — caution required

Mechanism

ACE inhibitors reduce renal blood flow and aldosterone-mediated sodium excretion, increasing proximal tubular reabsorpti...

Action

Check lithium concentration within one week of starting an ACE inhibitor and adjust dose. Maintain adequate hydration an...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Enalapril and Lithium together?

With caution. Check lithium concentration within one week of starting an ACE inhibitor and adjust dose. Maintain adequate hydration and avoid concurrent NSAIDs.

What is the severity of this interaction?

The interaction between Enalapril and Lithium is classified as Moderate — caution required. ACE inhibitors reduce renal blood flow and aldosterone-mediated sodium excretion, increasing proximal tubular reabsorption of lithium and raising plasma levels.

What should I do if I'm prescribed both?

Check lithium concentration within one week of starting an ACE inhibitor and adjust dose. Maintain adequate hydration and avoid concurrent NSAIDs. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.