Enzalutamide and Rivaroxaban: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Enzalutamide and Rivaroxaban unless specifically directed by your doctor.
How Enzalutamide interacts with Rivaroxaban
Enzalutamide strongly induces CYP3A4, increasing rivaroxaban metabolism and potentially reducing anticoagulant exposure and efficacy.
What you should do
Avoid the combination because routine coagulation tests cannot reliably guide dose adjustment. Select an anticoagulant strategy appropriate for use with strong enzyme inducers.
Key facts
Severity
Major — avoid combination
Mechanism
Enzalutamide strongly induces CYP3A4, increasing rivaroxaban metabolism and potentially reducing anticoagulant exposure ...
Action
Avoid the combination because routine coagulation tests cannot reliably guide dose adjustment. Select an anticoagulant s...
Frequently asked questions
Can I take Enzalutamide and Rivaroxaban together?
No — this combination should generally be avoided. Avoid the combination because routine coagulation tests cannot reliably guide dose adjustment. Select an anticoagulant strategy appropriate for use with strong enzyme inducers.
What is the severity of this interaction?
The interaction between Enzalutamide and Rivaroxaban is classified as Major — avoid combination. Enzalutamide strongly induces CYP3A4, increasing rivaroxaban metabolism and potentially reducing anticoagulant exposure and efficacy.
What should I do if I'm prescribed both?
Avoid the combination because routine coagulation tests cannot reliably guide dose adjustment. Select an anticoagulant strategy appropriate for use with strong enzyme inducers. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.