Epinephrine and Propranolol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Epinephrine and Propranolol unless specifically directed by your doctor.
How Epinephrine interacts with Propranolol
Non-selective beta-blockade leaves alpha-1-mediated vasoconstriction unopposed when epinephrine is given, causing severe hypertension and reflex bradycardia.
What you should do
Use cardioselective beta-blockers when epinephrine may be required (e.g., anaphylaxis-prone patients). If hypertensive crisis occurs, treat with phentolamine.
Key facts
Severity
Major — avoid combination
Mechanism
Non-selective beta-blockade leaves alpha-1-mediated vasoconstriction unopposed when epinephrine is given, causing severe...
Action
Use cardioselective beta-blockers when epinephrine may be required (e.g., anaphylaxis-prone patients). If hypertensive c...
Frequently asked questions
Can I take Epinephrine and Propranolol together?
No — this combination should generally be avoided. Use cardioselective beta-blockers when epinephrine may be required (e.g., anaphylaxis-prone patients). If hypertensive crisis occurs, treat with phentolamine.
What is the severity of this interaction?
The interaction between Epinephrine and Propranolol is classified as Major — avoid combination. Non-selective beta-blockade leaves alpha-1-mediated vasoconstriction unopposed when epinephrine is given, causing severe hypertension and reflex bradycardia.
What should I do if I'm prescribed both?
Use cardioselective beta-blockers when epinephrine may be required (e.g., anaphylaxis-prone patients). If hypertensive crisis occurs, treat with phentolamine. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.