Propranolol and Verapamil: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Propranolol and Verapamil unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Propranolol interacts with Verapamil

Beta-blockade combined with non-dihydropyridine calcium channel blockade produces additive negative inotropic, chronotropic, and dromotropic effects on the heart.

What you should do

Avoid combination, particularly intravenously; use only with caution in patients with normal ventricular function under cardiology monitoring.

Key facts

Severity

Major — avoid combination

Mechanism

Beta-blockade combined with non-dihydropyridine calcium channel blockade produces additive negative inotropic, chronotro...

Action

Avoid combination, particularly intravenously; use only with caution in patients with normal ventricular function under ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Propranolol and Verapamil together?

No — this combination should generally be avoided. Avoid combination, particularly intravenously; use only with caution in patients with normal ventricular function under cardiology monitoring.

What is the severity of this interaction?

The interaction between Propranolol and Verapamil is classified as Major — avoid combination. Beta-blockade combined with non-dihydropyridine calcium channel blockade produces additive negative inotropic, chronotropic, and dromotropic effects on the heart.

What should I do if I'm prescribed both?

Avoid combination, particularly intravenously; use only with caution in patients with normal ventricular function under cardiology monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.