Erythromycin and Tacrolimus: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Erythromycin and Tacrolimus unless specifically directed by your doctor.
How Erythromycin interacts with Tacrolimus
Erythromycin inhibits CYP3A4 and P-glycoprotein, significantly increasing tacrolimus blood concentrations and risk of nephrotoxicity and neurotoxicity.
What you should do
Avoid combination where possible; if required, reduce tacrolimus dose by 50% and check trough level within 2-3 days.
Key facts
Severity
Major — avoid combination
Mechanism
Erythromycin inhibits CYP3A4 and P-glycoprotein, significantly increasing tacrolimus blood concentrations and risk of ne...
Action
Avoid combination where possible; if required, reduce tacrolimus dose by 50% and check trough level within 2-3 days.
Frequently asked questions
Can I take Erythromycin and Tacrolimus together?
No — this combination should generally be avoided. Avoid combination where possible; if required, reduce tacrolimus dose by 50% and check trough level within 2-3 days.
What is the severity of this interaction?
The interaction between Erythromycin and Tacrolimus is classified as Major — avoid combination. Erythromycin inhibits CYP3A4 and P-glycoprotein, significantly increasing tacrolimus blood concentrations and risk of nephrotoxicity and neurotoxicity.
What should I do if I'm prescribed both?
Avoid combination where possible; if required, reduce tacrolimus dose by 50% and check trough level within 2-3 days. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.