Fluconazole and Methadone: Drug Interaction Guide

Quick answer: This combination requires caution. Fluconazole and Methadone can be used together with adjustments and monitoring.

How Fluconazole interacts with Methadone

Fluconazole inhibits CYP-mediated methadone metabolism, increasing methadone exposure and risk of sedation, respiratory depression, and QT prolongation.

What you should do

Monitor for opioid toxicity and QT risk. Consider methadone dose reduction in symptomatic or high-risk patients.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP-mediated methadone metabolism, increasing methadone exposure and risk of sedation, respiratory ...

Action

Monitor for opioid toxicity and QT risk. Consider methadone dose reduction in symptomatic or high-risk patients.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Fluconazole and Methadone together?

With caution. Monitor for opioid toxicity and QT risk. Consider methadone dose reduction in symptomatic or high-risk patients.

What is the severity of this interaction?

The interaction between Fluconazole and Methadone is classified as Moderate — caution required. Fluconazole inhibits CYP-mediated methadone metabolism, increasing methadone exposure and risk of sedation, respiratory depression, and QT prolongation.

What should I do if I'm prescribed both?

Monitor for opioid toxicity and QT risk. Consider methadone dose reduction in symptomatic or high-risk patients. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 22, 2026 by iMedic Medical Editorial Team. Our editorial process.