Methadone and Voriconazole: Drug Interaction Guide

Quick answer: This combination requires caution. Methadone and Voriconazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Methadone interacts with Voriconazole

Voriconazole inhibits CYP3A4 and CYP2B6 pathways involved in methadone metabolism. Methadone exposure may increase, raising risk of sedation, respiratory depression, and QT prolongation.

What you should do

Monitor for opioid toxicity and QT prolongation when starting voriconazole. Consider methadone dose reduction and ECG monitoring in patients with additional risk factors.

Key facts

Severity

Moderate — caution required

Mechanism

Voriconazole inhibits CYP3A4 and CYP2B6 pathways involved in methadone metabolism. Methadone exposure may increase, rais...

Action

Monitor for opioid toxicity and QT prolongation when starting voriconazole. Consider methadone dose reduction and ECG mo...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Methadone and Voriconazole together?

With caution. Monitor for opioid toxicity and QT prolongation when starting voriconazole. Consider methadone dose reduction and ECG monitoring in patients with additional risk factors.

What is the severity of this interaction?

The interaction between Methadone and Voriconazole is classified as Moderate — caution required. Voriconazole inhibits CYP3A4 and CYP2B6 pathways involved in methadone metabolism. Methadone exposure may increase, raising risk of sedation, respiratory depression, and QT prolongation.

What should I do if I'm prescribed both?

Monitor for opioid toxicity and QT prolongation when starting voriconazole. Consider methadone dose reduction and ECG monitoring in patients with additional risk factors. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.