Fluconazole and Simvastatin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Fluconazole and Simvastatin unless specifically directed by your doctor.
How Fluconazole interacts with Simvastatin
Fluconazole inhibits CYP3A4 metabolism of simvastatin, dramatically increasing systemic exposure and the risk of rhabdomyolysis and acute kidney injury.
What you should do
Hold simvastatin during short-course fluconazole therapy; for chronic combinations, switch to pravastatin or rosuvastatin which are not significantly CYP3A4-metabolised.
Key facts
Severity
Major — avoid combination
Mechanism
Fluconazole inhibits CYP3A4 metabolism of simvastatin, dramatically increasing systemic exposure and the risk of rhabdom...
Action
Hold simvastatin during short-course fluconazole therapy; for chronic combinations, switch to pravastatin or rosuvastati...
Frequently asked questions
Can I take Fluconazole and Simvastatin together?
No — this combination should generally be avoided. Hold simvastatin during short-course fluconazole therapy; for chronic combinations, switch to pravastatin or rosuvastatin which are not significantly CYP3A4-metabolised.
What is the severity of this interaction?
The interaction between Fluconazole and Simvastatin is classified as Major — avoid combination. Fluconazole inhibits CYP3A4 metabolism of simvastatin, dramatically increasing systemic exposure and the risk of rhabdomyolysis and acute kidney injury.
What should I do if I'm prescribed both?
Hold simvastatin during short-course fluconazole therapy; for chronic combinations, switch to pravastatin or rosuvastatin which are not significantly CYP3A4-metabolised. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.