Fluoxetine and Propranolol: Drug Interaction Guide

Quick answer: This combination requires caution. Fluoxetine and Propranolol can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Fluoxetine interacts with Propranolol

Fluoxetine inhibits CYP2D6, reducing propranolol metabolism. Increased beta-blocker exposure can cause bradycardia, hypotension, and fatigue.

What you should do

Start with lower propranolol doses, monitor heart rate and blood pressure, and adjust based on tolerability.

Key facts

Severity

Moderate — caution required

Mechanism

Fluoxetine inhibits CYP2D6, reducing propranolol metabolism. Increased beta-blocker exposure can cause bradycardia, hypo...

Action

Start with lower propranolol doses, monitor heart rate and blood pressure, and adjust based on tolerability.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Fluoxetine and Propranolol together?

With caution. Start with lower propranolol doses, monitor heart rate and blood pressure, and adjust based on tolerability.

What is the severity of this interaction?

The interaction between Fluoxetine and Propranolol is classified as Moderate — caution required. Fluoxetine inhibits CYP2D6, reducing propranolol metabolism. Increased beta-blocker exposure can cause bradycardia, hypotension, and fatigue.

What should I do if I'm prescribed both?

Start with lower propranolol doses, monitor heart rate and blood pressure, and adjust based on tolerability. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.