Fluvoxamine and Tizanidine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Fluvoxamine and Tizanidine unless specifically directed by your doctor.
How Fluvoxamine interacts with Tizanidine
Fluvoxamine is a potent CYP1A2 inhibitor and markedly increases tizanidine exposure, leading to severe hypotension, bradycardia and sedation.
What you should do
Combination is contraindicated; choose a non-CYP1A2 inhibitor antidepressant such as sertraline, or an alternative muscle relaxant.
Key facts
Severity
Major — avoid combination
Mechanism
Fluvoxamine is a potent CYP1A2 inhibitor and markedly increases tizanidine exposure, leading to severe hypotension, brad...
Action
Combination is contraindicated; choose a non-CYP1A2 inhibitor antidepressant such as sertraline, or an alternative muscl...
Frequently asked questions
Can I take Fluvoxamine and Tizanidine together?
No — this combination should generally be avoided. Combination is contraindicated; choose a non-CYP1A2 inhibitor antidepressant such as sertraline, or an alternative muscle relaxant.
What is the severity of this interaction?
The interaction between Fluvoxamine and Tizanidine is classified as Major — avoid combination. Fluvoxamine is a potent CYP1A2 inhibitor and markedly increases tizanidine exposure, leading to severe hypotension, bradycardia and sedation.
What should I do if I'm prescribed both?
Combination is contraindicated; choose a non-CYP1A2 inhibitor antidepressant such as sertraline, or an alternative muscle relaxant. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.