Quinolones and Tizanidine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Quinolones and Tizanidine unless specifically directed by your doctor.
How Quinolones interacts with Tizanidine
Ciprofloxacin and other fluoroquinolones are potent CYP1A2 inhibitors, dramatically increasing tizanidine exposure and causing severe hypotension and sedation.
What you should do
Coadministration of tizanidine with ciprofloxacin or fluvoxamine is contraindicated; choose an alternative antibiotic (e.g., levofloxacin) or a different muscle relaxant.
Key facts
Severity
Major — avoid combination
Mechanism
Ciprofloxacin and other fluoroquinolones are potent CYP1A2 inhibitors, dramatically increasing tizanidine exposure and c...
Action
Coadministration of tizanidine with ciprofloxacin or fluvoxamine is contraindicated; choose an alternative antibiotic (e...
Frequently asked questions
Can I take Quinolones and Tizanidine together?
No — this combination should generally be avoided. Coadministration of tizanidine with ciprofloxacin or fluvoxamine is contraindicated; choose an alternative antibiotic (e.g., levofloxacin) or a different muscle relaxant.
What is the severity of this interaction?
The interaction between Quinolones and Tizanidine is classified as Major — avoid combination. Ciprofloxacin and other fluoroquinolones are potent CYP1A2 inhibitors, dramatically increasing tizanidine exposure and causing severe hypotension and sedation.
What should I do if I'm prescribed both?
Coadministration of tizanidine with ciprofloxacin or fluvoxamine is contraindicated; choose an alternative antibiotic (e.g., levofloxacin) or a different muscle relaxant. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.