Gabapentin and Oxycodone: Drug Interaction Guide
Quick answer: This combination requires caution. Gabapentin and Oxycodone can be used together with adjustments and monitoring.
How Gabapentin interacts with Oxycodone
The interaction is mainly pharmacodynamic, with additive central nervous system and respiratory depressant effects. Opioids may also increase gabapentin exposure by slowing gastrointestinal motility.
What you should do
Use the lowest effective doses, avoid other sedatives, and monitor for excessive sedation, impaired coordination, and respiratory depression.
Key facts
Severity
Moderate — caution required
Mechanism
The interaction is mainly pharmacodynamic, with additive central nervous system and respiratory depressant effects. Opio...
Action
Use the lowest effective doses, avoid other sedatives, and monitor for excessive sedation, impaired coordination, and re...
Frequently asked questions
Can I take Gabapentin and Oxycodone together?
With caution. Use the lowest effective doses, avoid other sedatives, and monitor for excessive sedation, impaired coordination, and respiratory depression.
What is the severity of this interaction?
The interaction between Gabapentin and Oxycodone is classified as Moderate — caution required. The interaction is mainly pharmacodynamic, with additive central nervous system and respiratory depressant effects. Opioids may also increase gabapentin exposure by slowing gastrointestinal motility.
What should I do if I'm prescribed both?
Use the lowest effective doses, avoid other sedatives, and monitor for excessive sedation, impaired coordination, and respiratory depression. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.