Oxycodone and Paroxetine: Drug Interaction Guide

Quick answer: This combination requires caution. Oxycodone and Paroxetine can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Oxycodone interacts with Paroxetine

Paroxetine strongly inhibits CYP2D6, reducing formation of oxymorphone from oxycodone. Additive central nervous system depression may still occur, and analgesic response can become unpredictable.

What you should do

Monitor pain control, sedation, and respiratory status after starting or stopping paroxetine. Consider an opioid less dependent on CYP2D6 or a non-opioid analgesic strategy.

Key facts

Severity

Moderate — caution required

Mechanism

Paroxetine strongly inhibits CYP2D6, reducing formation of oxymorphone from oxycodone. Additive central nervous system d...

Action

Monitor pain control, sedation, and respiratory status after starting or stopping paroxetine. Consider an opioid less de...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Oxycodone and Paroxetine together?

With caution. Monitor pain control, sedation, and respiratory status after starting or stopping paroxetine. Consider an opioid less dependent on CYP2D6 or a non-opioid analgesic strategy.

What is the severity of this interaction?

The interaction between Oxycodone and Paroxetine is classified as Moderate — caution required. Paroxetine strongly inhibits CYP2D6, reducing formation of oxymorphone from oxycodone. Additive central nervous system depression may still occur, and analgesic response can become unpredictable.

What should I do if I'm prescribed both?

Monitor pain control, sedation, and respiratory status after starting or stopping paroxetine. Consider an opioid less dependent on CYP2D6 or a non-opioid analgesic strategy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.