Gemfibrozil and Simvastatin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Gemfibrozil and Simvastatin unless specifically directed by your doctor.
How Gemfibrozil interacts with Simvastatin
Gemfibrozil inhibits OATP1B1 hepatic uptake and CYP-mediated metabolism of simvastatin, while also independently increasing skeletal muscle toxicity risk.
What you should do
Combination is contraindicated. Use fenofibrate plus a statin if combined lipid therapy is required, with creatine kinase monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Gemfibrozil inhibits OATP1B1 hepatic uptake and CYP-mediated metabolism of simvastatin, while also independently increas...
Action
Combination is contraindicated. Use fenofibrate plus a statin if combined lipid therapy is required, with creatine kinas...
Frequently asked questions
Can I take Gemfibrozil and Simvastatin together?
No — this combination should generally be avoided. Combination is contraindicated. Use fenofibrate plus a statin if combined lipid therapy is required, with creatine kinase monitoring.
What is the severity of this interaction?
The interaction between Gemfibrozil and Simvastatin is classified as Major — avoid combination. Gemfibrozil inhibits OATP1B1 hepatic uptake and CYP-mediated metabolism of simvastatin, while also independently increasing skeletal muscle toxicity risk.
What should I do if I'm prescribed both?
Combination is contraindicated. Use fenofibrate plus a statin if combined lipid therapy is required, with creatine kinase monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.