Gentamicin and Tacrolimus: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Gentamicin and Tacrolimus unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Gentamicin interacts with Tacrolimus

Both agents are independently nephrotoxic and combine to produce additive proximal tubular injury and acute kidney injury.

What you should do

Avoid combination where possible. If essential, dose gentamicin by extended-interval protocol, monitor trough levels and check serum creatinine daily.

Key facts

Severity

Major — avoid combination

Mechanism

Both agents are independently nephrotoxic and combine to produce additive proximal tubular injury and acute kidney injur...

Action

Avoid combination where possible. If essential, dose gentamicin by extended-interval protocol, monitor trough levels and...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Gentamicin and Tacrolimus together?

No — this combination should generally be avoided. Avoid combination where possible. If essential, dose gentamicin by extended-interval protocol, monitor trough levels and check serum creatinine daily.

What is the severity of this interaction?

The interaction between Gentamicin and Tacrolimus is classified as Major — avoid combination. Both agents are independently nephrotoxic and combine to produce additive proximal tubular injury and acute kidney injury.

What should I do if I'm prescribed both?

Avoid combination where possible. If essential, dose gentamicin by extended-interval protocol, monitor trough levels and check serum creatinine daily. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.