Glibenclamide and Propranolol: Drug Interaction Guide

Quick answer: This combination requires caution. Glibenclamide and Propranolol can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Glibenclamide interacts with Propranolol

Propranolol blocks beta-adrenergic warning symptoms and counter-regulatory responses to glibenclamide-induced hypoglycaemia, potentially prolonging severe episodes.

What you should do

Prefer a cardioselective beta blocker when suitable and increase glucose monitoring. Counsel patients that sweating or neuroglycopenic symptoms may occur without tachycardia or tremor.

Key facts

Severity

Moderate — caution required

Mechanism

Propranolol blocks beta-adrenergic warning symptoms and counter-regulatory responses to glibenclamide-induced hypoglycae...

Action

Prefer a cardioselective beta blocker when suitable and increase glucose monitoring. Counsel patients that sweating or n...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Glibenclamide and Propranolol together?

With caution. Prefer a cardioselective beta blocker when suitable and increase glucose monitoring. Counsel patients that sweating or neuroglycopenic symptoms may occur without tachycardia or tremor.

What is the severity of this interaction?

The interaction between Glibenclamide and Propranolol is classified as Moderate — caution required. Propranolol blocks beta-adrenergic warning symptoms and counter-regulatory responses to glibenclamide-induced hypoglycaemia, potentially prolonging severe episodes.

What should I do if I'm prescribed both?

Prefer a cardioselective beta blocker when suitable and increase glucose monitoring. Counsel patients that sweating or neuroglycopenic symptoms may occur without tachycardia or tremor. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.