Glyceryl Trinitrate and Sildenafil: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Glyceryl Trinitrate and Sildenafil unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Glyceryl Trinitrate interacts with Sildenafil

Sildenafil potentiates the vasodilatory effect of nitric oxide donors via cGMP accumulation, producing profound and refractory hypotension.

What you should do

Co-administration is contraindicated. Wait at least 24 hours after sildenafil (48 hours for tadalafil) before administering any nitrate.

Key facts

Severity

Major — avoid combination

Mechanism

Sildenafil potentiates the vasodilatory effect of nitric oxide donors via cGMP accumulation, producing profound and refr...

Action

Co-administration is contraindicated. Wait at least 24 hours after sildenafil (48 hours for tadalafil) before administer...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Glyceryl Trinitrate and Sildenafil together?

No — this combination should generally be avoided. Co-administration is contraindicated. Wait at least 24 hours after sildenafil (48 hours for tadalafil) before administering any nitrate.

What is the severity of this interaction?

The interaction between Glyceryl Trinitrate and Sildenafil is classified as Major — avoid combination. Sildenafil potentiates the vasodilatory effect of nitric oxide donors via cGMP accumulation, producing profound and refractory hypotension.

What should I do if I'm prescribed both?

Co-administration is contraindicated. Wait at least 24 hours after sildenafil (48 hours for tadalafil) before administering any nitrate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.