Glyceryl Trinitrate and Tadalafil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Glyceryl Trinitrate and Tadalafil unless specifically directed by your doctor.
How Glyceryl Trinitrate interacts with Tadalafil
Glyceryl trinitrate increases nitric-oxide-mediated cyclic GMP production, while tadalafil inhibits PDE5-mediated cyclic GMP degradation, causing potentially profound hypotension.
What you should do
Concurrent use is contraindicated. Do not administer nitrates for at least 48 hours after tadalafil, and seek specialist guidance if nitrate treatment is medically essential.
Key facts
Severity
Major — avoid combination
Mechanism
Glyceryl trinitrate increases nitric-oxide-mediated cyclic GMP production, while tadalafil inhibits PDE5-mediated cyclic...
Action
Concurrent use is contraindicated. Do not administer nitrates for at least 48 hours after tadalafil, and seek specialist...
Frequently asked questions
Can I take Glyceryl Trinitrate and Tadalafil together?
No — this combination should generally be avoided. Concurrent use is contraindicated. Do not administer nitrates for at least 48 hours after tadalafil, and seek specialist guidance if nitrate treatment is medically essential.
What is the severity of this interaction?
The interaction between Glyceryl Trinitrate and Tadalafil is classified as Major — avoid combination. Glyceryl trinitrate increases nitric-oxide-mediated cyclic GMP production, while tadalafil inhibits PDE5-mediated cyclic GMP degradation, causing potentially profound hypotension.
What should I do if I'm prescribed both?
Concurrent use is contraindicated. Do not administer nitrates for at least 48 hours after tadalafil, and seek specialist guidance if nitrate treatment is medically essential. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.