Indomethacin and Lisinopril: Drug Interaction Guide

Quick answer: This combination requires caution. Indomethacin and Lisinopril can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Indomethacin interacts with Lisinopril

NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar vasodilation; combined with ACE inhibitor-induced efferent vasodilation this can cause acute kidney injury and blunt antihypertensive effect.

What you should do

Avoid chronic NSAID use in patients on ACE inhibitors, particularly with diuretics ('triple whammy'). If short-term use unavoidable, monitor renal function and blood pressure.

Key facts

Severity

Moderate — caution required

Mechanism

NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar vasodilation; combined with ACE inhibitor-ind...

Action

Avoid chronic NSAID use in patients on ACE inhibitors, particularly with diuretics ('triple whammy'). If short-term use ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Indomethacin and Lisinopril together?

With caution. Avoid chronic NSAID use in patients on ACE inhibitors, particularly with diuretics ('triple whammy'). If short-term use unavoidable, monitor renal function and blood pressure.

What is the severity of this interaction?

The interaction between Indomethacin and Lisinopril is classified as Moderate — caution required. NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar vasodilation; combined with ACE inhibitor-induced efferent vasodilation this can cause acute kidney injury and blunt antihypertensive effect.

What should I do if I'm prescribed both?

Avoid chronic NSAID use in patients on ACE inhibitors, particularly with diuretics ('triple whammy'). If short-term use unavoidable, monitor renal function and blood pressure. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.