Lisinopril and Naproxen: Drug Interaction Guide

Quick answer: This combination requires caution. Lisinopril and Naproxen can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Lisinopril interacts with Naproxen

NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar dilation and blunting ACE inhibitor effects on blood pressure and renal perfusion.

What you should do

Use the lowest NSAID dose for the shortest time and monitor blood pressure, renal function, and potassium.

Key facts

Severity

Moderate — caution required

Mechanism

NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar dilation and blunting ACE inhibitor effects o...

Action

Use the lowest NSAID dose for the shortest time and monitor blood pressure, renal function, and potassium.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lisinopril and Naproxen together?

With caution. Use the lowest NSAID dose for the shortest time and monitor blood pressure, renal function, and potassium.

What is the severity of this interaction?

The interaction between Lisinopril and Naproxen is classified as Moderate — caution required. NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar dilation and blunting ACE inhibitor effects on blood pressure and renal perfusion.

What should I do if I'm prescribed both?

Use the lowest NSAID dose for the shortest time and monitor blood pressure, renal function, and potassium. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.