Irbesartan and Lithium: Drug Interaction Guide

Quick answer: This combination requires caution. Irbesartan and Lithium can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Irbesartan interacts with Lithium

Angiotensin receptor blockers reduce renal lithium clearance via decreased glomerular filtration and increased proximal tubular reabsorption.

What you should do

Check lithium level within 5-7 days of starting or changing irbesartan dose, and monitor for tremor, confusion, and GI symptoms of toxicity.

Key facts

Severity

Moderate — caution required

Mechanism

Angiotensin receptor blockers reduce renal lithium clearance via decreased glomerular filtration and increased proximal ...

Action

Check lithium level within 5-7 days of starting or changing irbesartan dose, and monitor for tremor, confusion, and GI s...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Irbesartan and Lithium together?

With caution. Check lithium level within 5-7 days of starting or changing irbesartan dose, and monitor for tremor, confusion, and GI symptoms of toxicity.

What is the severity of this interaction?

The interaction between Irbesartan and Lithium is classified as Moderate — caution required. Angiotensin receptor blockers reduce renal lithium clearance via decreased glomerular filtration and increased proximal tubular reabsorption.

What should I do if I'm prescribed both?

Check lithium level within 5-7 days of starting or changing irbesartan dose, and monitor for tremor, confusion, and GI symptoms of toxicity. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.