Itraconazole and Rivaroxaban: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Itraconazole and Rivaroxaban unless specifically directed by your doctor.
How Itraconazole interacts with Rivaroxaban
Itraconazole inhibits CYP3A4 and P-glycoprotein, significantly increasing rivaroxaban plasma concentrations and haemorrhage risk.
What you should do
Avoid concomitant use; switch to an antifungal with less interaction potential (e.g. terbinafine) or use a different anticoagulant strategy.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole inhibits CYP3A4 and P-glycoprotein, significantly increasing rivaroxaban plasma concentrations and haemorrh...
Action
Avoid concomitant use; switch to an antifungal with less interaction potential (e.g. terbinafine) or use a different ant...
Frequently asked questions
Can I take Itraconazole and Rivaroxaban together?
No — this combination should generally be avoided. Avoid concomitant use; switch to an antifungal with less interaction potential (e.g. terbinafine) or use a different anticoagulant strategy.
What is the severity of this interaction?
The interaction between Itraconazole and Rivaroxaban is classified as Major — avoid combination. Itraconazole inhibits CYP3A4 and P-glycoprotein, significantly increasing rivaroxaban plasma concentrations and haemorrhage risk.
What should I do if I'm prescribed both?
Avoid concomitant use; switch to an antifungal with less interaction potential (e.g. terbinafine) or use a different anticoagulant strategy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.