Ketoconazole and Salmeterol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ketoconazole and Salmeterol unless specifically directed by your doctor.
How Ketoconazole interacts with Salmeterol
Ketoconazole strongly inhibits CYP3A4, increasing systemic exposure to salmeterol. Higher salmeterol concentrations can increase QT prolongation, palpitations, and tachyarrhythmia risk.
What you should do
Avoid the combination when possible; choose an alternative antifungal or bronchodilator and monitor cardiovascular symptoms if unavoidable.
Key facts
Severity
Major — avoid combination
Mechanism
Ketoconazole strongly inhibits CYP3A4, increasing systemic exposure to salmeterol. Higher salmeterol concentrations can ...
Action
Avoid the combination when possible; choose an alternative antifungal or bronchodilator and monitor cardiovascular sympt...
Frequently asked questions
Can I take Ketoconazole and Salmeterol together?
No — this combination should generally be avoided. Avoid the combination when possible; choose an alternative antifungal or bronchodilator and monitor cardiovascular symptoms if unavoidable.
What is the severity of this interaction?
The interaction between Ketoconazole and Salmeterol is classified as Major — avoid combination. Ketoconazole strongly inhibits CYP3A4, increasing systemic exposure to salmeterol. Higher salmeterol concentrations can increase QT prolongation, palpitations, and tachyarrhythmia risk.
What should I do if I'm prescribed both?
Avoid the combination when possible; choose an alternative antifungal or bronchodilator and monitor cardiovascular symptoms if unavoidable. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.