Salmeterol and Voriconazole: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Salmeterol and Voriconazole unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Salmeterol interacts with Voriconazole

Voriconazole inhibits CYP3A4, increasing systemic salmeterol exposure and risk of QT prolongation, tachyarrhythmia, and hypokalemia.

What you should do

Avoid the combination; use an alternative antifungal or bronchodilator strategy.

Key facts

Severity

Major — avoid combination

Mechanism

Voriconazole inhibits CYP3A4, increasing systemic salmeterol exposure and risk of QT prolongation, tachyarrhythmia, and ...

Action

Avoid the combination; use an alternative antifungal or bronchodilator strategy.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Salmeterol and Voriconazole together?

No — this combination should generally be avoided. Avoid the combination; use an alternative antifungal or bronchodilator strategy.

What is the severity of this interaction?

The interaction between Salmeterol and Voriconazole is classified as Major — avoid combination. Voriconazole inhibits CYP3A4, increasing systemic salmeterol exposure and risk of QT prolongation, tachyarrhythmia, and hypokalemia.

What should I do if I'm prescribed both?

Avoid the combination; use an alternative antifungal or bronchodilator strategy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.