Lansoprazole and Rilpivirine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Lansoprazole and Rilpivirine unless specifically directed by your doctor.
How Lansoprazole interacts with Rilpivirine
Proton pump inhibitors raise gastric pH, markedly reducing the dissolution and absorption of rilpivirine, which can result in virologic failure and resistance development.
What you should do
Co-administration of rilpivirine with any PPI is contraindicated; use an H2-receptor antagonist taken at least 12 hours before or 4 hours after rilpivirine if acid suppression is needed.
Key facts
Severity
Major — avoid combination
Mechanism
Proton pump inhibitors raise gastric pH, markedly reducing the dissolution and absorption of rilpivirine, which can resu...
Action
Co-administration of rilpivirine with any PPI is contraindicated; use an H2-receptor antagonist taken at least 12 hours ...
Frequently asked questions
Can I take Lansoprazole and Rilpivirine together?
No — this combination should generally be avoided. Co-administration of rilpivirine with any PPI is contraindicated; use an H2-receptor antagonist taken at least 12 hours before or 4 hours after rilpivirine if acid suppression is needed.
What is the severity of this interaction?
The interaction between Lansoprazole and Rilpivirine is classified as Major — avoid combination. Proton pump inhibitors raise gastric pH, markedly reducing the dissolution and absorption of rilpivirine, which can result in virologic failure and resistance development.
What should I do if I'm prescribed both?
Co-administration of rilpivirine with any PPI is contraindicated; use an H2-receptor antagonist taken at least 12 hours before or 4 hours after rilpivirine if acid suppression is needed. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.