Omeprazole and Rilpivirine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Omeprazole and Rilpivirine unless specifically directed by your doctor.
How Omeprazole interacts with Rilpivirine
Omeprazole increases gastric pH, reducing absorption of rilpivirine, which requires an acidic environment. This can lower antiretroviral exposure and risk virologic failure.
What you should do
Contraindicated. Use an alternative acid-suppressive strategy compatible with rilpivirine or select a different antiretroviral regimen.
Key facts
Severity
Major — avoid combination
Mechanism
Omeprazole increases gastric pH, reducing absorption of rilpivirine, which requires an acidic environment. This can lowe...
Action
Contraindicated. Use an alternative acid-suppressive strategy compatible with rilpivirine or select a different antiretr...
Frequently asked questions
Can I take Omeprazole and Rilpivirine together?
No — this combination should generally be avoided. Contraindicated. Use an alternative acid-suppressive strategy compatible with rilpivirine or select a different antiretroviral regimen.
What is the severity of this interaction?
The interaction between Omeprazole and Rilpivirine is classified as Major — avoid combination. Omeprazole increases gastric pH, reducing absorption of rilpivirine, which requires an acidic environment. This can lower antiretroviral exposure and risk virologic failure.
What should I do if I'm prescribed both?
Contraindicated. Use an alternative acid-suppressive strategy compatible with rilpivirine or select a different antiretroviral regimen. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.