Linezolid and Phenelzine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Linezolid and Phenelzine unless specifically directed by your doctor.
How Linezolid interacts with Phenelzine
Linezolid is a weak reversible MAO inhibitor; combined with another MAOI, it causes excessive serotonergic and adrenergic activity with risk of serotonin syndrome and hypertensive crisis.
What you should do
Contraindicated — discontinue phenelzine at least 2 weeks before starting linezolid, or use an alternative antibiotic.
Key facts
Severity
Major — avoid combination
Mechanism
Linezolid is a weak reversible MAO inhibitor; combined with another MAOI, it causes excessive serotonergic and adrenergi...
Action
Contraindicated — discontinue phenelzine at least 2 weeks before starting linezolid, or use an alternative antibiotic.
Frequently asked questions
Can I take Linezolid and Phenelzine together?
No — this combination should generally be avoided. Contraindicated — discontinue phenelzine at least 2 weeks before starting linezolid, or use an alternative antibiotic.
What is the severity of this interaction?
The interaction between Linezolid and Phenelzine is classified as Major — avoid combination. Linezolid is a weak reversible MAO inhibitor; combined with another MAOI, it causes excessive serotonergic and adrenergic activity with risk of serotonin syndrome and hypertensive crisis.
What should I do if I'm prescribed both?
Contraindicated — discontinue phenelzine at least 2 weeks before starting linezolid, or use an alternative antibiotic. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.