Phenelzine and Sertraline: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Phenelzine and Sertraline unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Phenelzine interacts with Sertraline

MAO inhibition combined with SSRI-mediated serotonin reuptake blockade causes excessive central serotonergic activity, precipitating life-threatening serotonin syndrome.

What you should do

Contraindicated. Allow 14-day washout after phenelzine before starting sertraline and 5 weeks after sertraline before starting an MAOI.

Key facts

Severity

Major — avoid combination

Mechanism

MAO inhibition combined with SSRI-mediated serotonin reuptake blockade causes excessive central serotonergic activity, p...

Action

Contraindicated. Allow 14-day washout after phenelzine before starting sertraline and 5 weeks after sertraline before st...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Phenelzine and Sertraline together?

No — this combination should generally be avoided. Contraindicated. Allow 14-day washout after phenelzine before starting sertraline and 5 weeks after sertraline before starting an MAOI.

What is the severity of this interaction?

The interaction between Phenelzine and Sertraline is classified as Major — avoid combination. MAO inhibition combined with SSRI-mediated serotonin reuptake blockade causes excessive central serotonergic activity, precipitating life-threatening serotonin syndrome.

What should I do if I'm prescribed both?

Contraindicated. Allow 14-day washout after phenelzine before starting sertraline and 5 weeks after sertraline before starting an MAOI. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.