Lopinavir and Simvastatin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Lopinavir and Simvastatin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Lopinavir interacts with Simvastatin

Lopinavir boosted with ritonavir strongly inhibits CYP3A4, causing large increases in simvastatin exposure and risk of rhabdomyolysis.

What you should do

Contraindicate or avoid simvastatin. Use pravastatin or carefully dosed rosuvastatin according to HIV interaction guidance.

Key facts

Severity

Major — avoid combination

Mechanism

Lopinavir boosted with ritonavir strongly inhibits CYP3A4, causing large increases in simvastatin exposure and risk of r...

Action

Contraindicate or avoid simvastatin. Use pravastatin or carefully dosed rosuvastatin according to HIV interaction guidan...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lopinavir and Simvastatin together?

No — this combination should generally be avoided. Contraindicate or avoid simvastatin. Use pravastatin or carefully dosed rosuvastatin according to HIV interaction guidance.

What is the severity of this interaction?

The interaction between Lopinavir and Simvastatin is classified as Major — avoid combination. Lopinavir boosted with ritonavir strongly inhibits CYP3A4, causing large increases in simvastatin exposure and risk of rhabdomyolysis.

What should I do if I'm prescribed both?

Contraindicate or avoid simvastatin. Use pravastatin or carefully dosed rosuvastatin according to HIV interaction guidance. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.