Lopinavir Ritonavir and Rivaroxaban: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Lopinavir Ritonavir and Rivaroxaban unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Lopinavir Ritonavir interacts with Rivaroxaban

Ritonavir potently inhibits both CYP3A4 and P-glycoprotein, more than doubling rivaroxaban exposure and significantly increasing major bleeding risk.

What you should do

Avoid rivaroxaban in patients on ritonavir-boosted regimens; use apixaban with caution or LMWH/warfarin as alternatives.

Key facts

Severity

Major — avoid combination

Mechanism

Ritonavir potently inhibits both CYP3A4 and P-glycoprotein, more than doubling rivaroxaban exposure and significantly in...

Action

Avoid rivaroxaban in patients on ritonavir-boosted regimens; use apixaban with caution or LMWH/warfarin as alternatives.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lopinavir Ritonavir and Rivaroxaban together?

No — this combination should generally be avoided. Avoid rivaroxaban in patients on ritonavir-boosted regimens; use apixaban with caution or LMWH/warfarin as alternatives.

What is the severity of this interaction?

The interaction between Lopinavir Ritonavir and Rivaroxaban is classified as Major — avoid combination. Ritonavir potently inhibits both CYP3A4 and P-glycoprotein, more than doubling rivaroxaban exposure and significantly increasing major bleeding risk.

What should I do if I'm prescribed both?

Avoid rivaroxaban in patients on ritonavir-boosted regimens; use apixaban with caution or LMWH/warfarin as alternatives. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.