Lopinavir Ritonavir and Rifampicin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Lopinavir Ritonavir and Rifampicin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Lopinavir Ritonavir interacts with Rifampicin

Rifampicin is a potent CYP3A4 and P-glycoprotein inducer, dramatically reducing protease inhibitor exposure and risking HIV virological failure.

What you should do

Avoid combination; substitute rifabutin for rifampicin in HIV/TB co-treatment and adjust antiretroviral regimen with specialist input.

Key facts

Severity

Major — avoid combination

Mechanism

Rifampicin is a potent CYP3A4 and P-glycoprotein inducer, dramatically reducing protease inhibitor exposure and risking ...

Action

Avoid combination; substitute rifabutin for rifampicin in HIV/TB co-treatment and adjust antiretroviral regimen with spe...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lopinavir Ritonavir and Rifampicin together?

No — this combination should generally be avoided. Avoid combination; substitute rifabutin for rifampicin in HIV/TB co-treatment and adjust antiretroviral regimen with specialist input.

What is the severity of this interaction?

The interaction between Lopinavir Ritonavir and Rifampicin is classified as Major — avoid combination. Rifampicin is a potent CYP3A4 and P-glycoprotein inducer, dramatically reducing protease inhibitor exposure and risking HIV virological failure.

What should I do if I'm prescribed both?

Avoid combination; substitute rifabutin for rifampicin in HIV/TB co-treatment and adjust antiretroviral regimen with specialist input. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.