Meperidine and Phenelzine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Meperidine and Phenelzine unless specifically directed by your doctor.
How Meperidine interacts with Phenelzine
Meperidine (pethidine) inhibits neuronal serotonin reuptake, and combined with an irreversible MAO-A inhibitor like phenelzine can cause severe serotonin syndrome and hypertensive crisis.
What you should do
Combination is contraindicated; allow at least 14 days washout after stopping phenelzine before using meperidine and choose morphine or fentanyl as safer alternative opioids.
Key facts
Severity
Major — avoid combination
Mechanism
Meperidine (pethidine) inhibits neuronal serotonin reuptake, and combined with an irreversible MAO-A inhibitor like phen...
Action
Combination is contraindicated; allow at least 14 days washout after stopping phenelzine before using meperidine and cho...
Frequently asked questions
Can I take Meperidine and Phenelzine together?
No — this combination should generally be avoided. Combination is contraindicated; allow at least 14 days washout after stopping phenelzine before using meperidine and choose morphine or fentanyl as safer alternative opioids.
What is the severity of this interaction?
The interaction between Meperidine and Phenelzine is classified as Major — avoid combination. Meperidine (pethidine) inhibits neuronal serotonin reuptake, and combined with an irreversible MAO-A inhibitor like phenelzine can cause severe serotonin syndrome and hypertensive crisis.
What should I do if I'm prescribed both?
Combination is contraindicated; allow at least 14 days washout after stopping phenelzine before using meperidine and choose morphine or fentanyl as safer alternative opioids. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.