Metoclopramide and Quetiapine: Drug Interaction Guide

Quick answer: This combination requires caution. Metoclopramide and Quetiapine can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Metoclopramide interacts with Quetiapine

Both drugs antagonize dopamine D2 receptors, increasing the risk of extrapyramidal symptoms and tardive dyskinesia. Additive sedation may also occur.

What you should do

Avoid prolonged combined use and monitor for rigidity, akathisia, tremor and abnormal movements.

Key facts

Severity

Moderate — caution required

Mechanism

Both drugs antagonize dopamine D2 receptors, increasing the risk of extrapyramidal symptoms and tardive dyskinesia. Addi...

Action

Avoid prolonged combined use and monitor for rigidity, akathisia, tremor and abnormal movements.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Metoclopramide and Quetiapine together?

With caution. Avoid prolonged combined use and monitor for rigidity, akathisia, tremor and abnormal movements.

What is the severity of this interaction?

The interaction between Metoclopramide and Quetiapine is classified as Moderate — caution required. Both drugs antagonize dopamine D2 receptors, increasing the risk of extrapyramidal symptoms and tardive dyskinesia. Additive sedation may also occur.

What should I do if I'm prescribed both?

Avoid prolonged combined use and monitor for rigidity, akathisia, tremor and abnormal movements. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.