Metoprolol and Mirabegron: Drug Interaction Guide

Quick answer: This combination requires caution. Metoprolol and Mirabegron can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Metoprolol interacts with Mirabegron

Mirabegron is a moderate CYP2D6 inhibitor, increasing exposure to CYP2D6 substrates such as metoprolol with potential for excessive beta-blockade.

What you should do

Monitor heart rate and blood pressure when initiating mirabegron in patients on metoprolol; consider dose reduction of metoprolol if symptomatic bradycardia/hypotension.

Key facts

Severity

Moderate — caution required

Mechanism

Mirabegron is a moderate CYP2D6 inhibitor, increasing exposure to CYP2D6 substrates such as metoprolol with potential fo...

Action

Monitor heart rate and blood pressure when initiating mirabegron in patients on metoprolol; consider dose reduction of m...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Metoprolol and Mirabegron together?

With caution. Monitor heart rate and blood pressure when initiating mirabegron in patients on metoprolol; consider dose reduction of metoprolol if symptomatic bradycardia/hypotension.

What is the severity of this interaction?

The interaction between Metoprolol and Mirabegron is classified as Moderate — caution required. Mirabegron is a moderate CYP2D6 inhibitor, increasing exposure to CYP2D6 substrates such as metoprolol with potential for excessive beta-blockade.

What should I do if I'm prescribed both?

Monitor heart rate and blood pressure when initiating mirabegron in patients on metoprolol; consider dose reduction of metoprolol if symptomatic bradycardia/hypotension. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.