Metoprolol and Paroxetine: Drug Interaction Guide
Quick answer: This combination requires caution. Metoprolol and Paroxetine can be used together with adjustments and monitoring.
How Metoprolol interacts with Paroxetine
Paroxetine is a potent CYP2D6 inhibitor and metoprolol is a CYP2D6 substrate; co-administration increases metoprolol AUC up to 5-fold, risking bradycardia and hypotension.
What you should do
Monitor heart rate and blood pressure; reduce metoprolol dose if symptomatic bradycardia or hypotension occurs. Consider bisoprolol as an alternative beta-blocker.
Key facts
Severity
Moderate — caution required
Mechanism
Paroxetine is a potent CYP2D6 inhibitor and metoprolol is a CYP2D6 substrate; co-administration increases metoprolol AUC...
Action
Monitor heart rate and blood pressure; reduce metoprolol dose if symptomatic bradycardia or hypotension occurs. Consider...
Frequently asked questions
Can I take Metoprolol and Paroxetine together?
With caution. Monitor heart rate and blood pressure; reduce metoprolol dose if symptomatic bradycardia or hypotension occurs. Consider bisoprolol as an alternative beta-blocker.
What is the severity of this interaction?
The interaction between Metoprolol and Paroxetine is classified as Moderate — caution required. Paroxetine is a potent CYP2D6 inhibitor and metoprolol is a CYP2D6 substrate; co-administration increases metoprolol AUC up to 5-fold, risking bradycardia and hypotension.
What should I do if I'm prescribed both?
Monitor heart rate and blood pressure; reduce metoprolol dose if symptomatic bradycardia or hypotension occurs. Consider bisoprolol as an alternative beta-blocker. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.