Nirmatrelvir Ritonavir and Rosuvastatin: Drug Interaction Guide

Quick answer: This combination requires caution. Nirmatrelvir Ritonavir and Rosuvastatin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Nirmatrelvir Ritonavir interacts with Rosuvastatin

Ritonavir inhibits drug transporters including BCRP and OATP1B1, which can increase rosuvastatin exposure. This raises the risk of myopathy and rhabdomyolysis.

What you should do

Hold rosuvastatin during nirmatrelvir-ritonavir treatment or use a reduced dose with monitoring. Restart at the usual dose after the interaction window has passed.

Key facts

Severity

Moderate — caution required

Mechanism

Ritonavir inhibits drug transporters including BCRP and OATP1B1, which can increase rosuvastatin exposure. This raises t...

Action

Hold rosuvastatin during nirmatrelvir-ritonavir treatment or use a reduced dose with monitoring. Restart at the usual do...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Nirmatrelvir Ritonavir and Rosuvastatin together?

With caution. Hold rosuvastatin during nirmatrelvir-ritonavir treatment or use a reduced dose with monitoring. Restart at the usual dose after the interaction window has passed.

What is the severity of this interaction?

The interaction between Nirmatrelvir Ritonavir and Rosuvastatin is classified as Moderate — caution required. Ritonavir inhibits drug transporters including BCRP and OATP1B1, which can increase rosuvastatin exposure. This raises the risk of myopathy and rhabdomyolysis.

What should I do if I'm prescribed both?

Hold rosuvastatin during nirmatrelvir-ritonavir treatment or use a reduced dose with monitoring. Restart at the usual dose after the interaction window has passed. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.